GTPγS BindingGTPγS BindingGTPγS BindingGTPγS BindingGTPγS BindingGTPγS BindingGTPγS BindingGTPγS BindingGTPγS BindingGTPγS BindingGTPγS BindingGTPγS BindingGTPγS BindingGTPγS BindingGTPγS BindingGTPγS BindingGTPγS BindingGTPγS BindingGTPγS Binding

HTS056M - ChemiScreen™ FPRL1 N-Formylpeptide Receptor Membrane Preparation

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$646.90
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HTS056M
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    FPRL1 (formyl peptide receptor-like 1, also known as FPR2) is a GPCR that belongs to the N-formyl peptide receptor family. Initially described as a receptor for lipoxin A4, FPRL1 has been shown to bind to a synthetic peptide WKYMVm, amyloid beta peptides, and N-formylated mitochondrial peptides and mediates phagocyte chemotaxis (Fiore et al., 1994; Le et al., 1999; Rabiet et al., 2005; Iribarren et al., 2005). FPRL1 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of FPRL1 interactions with its ligands.

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    Item Unit of Measure: EA
    Quantity: 200 units
    Storage: On receipt of material store at -70°C. Unopened reagent is stable for a minimum of 1 year from date of shipment when stored at recommended storage temperature. Avoid repeat freeze/thaw cycles. For maximum recovery of product, centrifuge original vial
    Applications: GTPγS Binding
    Species: Human FPRL1 (Accession Number: NM_001462)
    Host Cell: Chem-1, an adherent mammalian cell line without any endogenous FPRL1 expression.
    Reference 1: 1. Fiore S et al. (1994) Identification of a human cDNA encoding a functional high affinity lipoxin A receptor. J. Exp. Med. 180: 253-260.
    Reference 2: 2. Iribarren P et al. (2005) Role of formyl peptide receptor-like 1 (FPRL1/FPR2) in mononuclear phagocyte responses in Alzheimer disease. Immunol. Res. 31: 165-76.
    Reference 3: 3. Le Y et al. (1999) Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and formyl peptide recptor, byt the synthetic hexapeptide WKYMVm for human phagocyte activation. J. Immunol. 163: 6777-6784.
    Reference 4: 4. Rabiet MJ et al. (2005) Human mitochondria-derived N-formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes-derived peptides preferentially activate FPR. Eur. J. Immunol. 35: 2486-95.
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