HTS002M - ChemiScreen™ CXCR2 Membrane Preparation

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$646.90
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HTS002M
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5 unit(s)
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    CXCR2 is a 7-TM G-protein coupled receptor that binds to the chemokines GROalpha, GRObeta, GROgamma, IL-8, ENA-78, NAP-2 and GCP-2 (Olson and Ley, 2002). Neutrophils, mast cells and microvascular endothelial cells express CXCR2, and interactions of CXCR2 with its ligands promotes chemotaxis of these cell types (Heidemann et al., 2003; Nilsson et al., 1999; White et al., 1998). Studies with mice lacking CXCR2 indicate that CXCR2 promotes growth of primary tumors and secondary metastases (Keane et al., 2004), and plays an essential role in hyperoxia-induced lung injury (Sue et al., 2004). In addition, cytomegalovirus encodes a CXCR2-binding chemokine, vCXC-1, that promotes neutrophil migration to infected cells (Penfold et al., 1999). Chemicon's CXCR2 Membrane Preps are ideal tools for screening for antagonists of interactions between CXCR2 and its ligands. Radiolabeled IL-8 binds to the CXCR2 membranes with a Kd of 0.075 nM. With 0.1 nM 125I-labeled IL-8, a 5-fold window of specific binding is obtained.

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    Item Unit of Measure: EA
    Quantity: 200 units
    Contents: 2 vials of mycoplasma-free cells, 1 mL per vial.
    Storage: On receipt of material store at -70°C. Unopened reagent is stable for a minimum of 1 year from date of shipment when stored at recommended storage temperature. Avoid repeat freeze/thaw cycles. For maximum recovery of product, centrifuge original vial
    Applications: Radioligand Binding Assay
    Entrez Gene Number: NM_001557.2
    Gene Symbol: IL8RB, CDw128b, CXCR2, IL8R2, IL8RA, CXCR-2, CMKAR2, CD182
    UniProt Number: P25025
    Protein Targets: CXCR2 / IL-8b
    Target Sub-family: Chemokine
    Host Cell: Chem-1
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