CYL3069 - PrecisION™ hKv4.3/hKChIP2-HEK Recombinant Stable Cell Line

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  • Product Description

    Recombinant HEK293 cell line co-expressing the human Kv4.3 (voltage-gated potassium channel, accession number NM_004980) and the human Kv channel interacting protein KChIP2 (accession number NM_173192).

    Additional Resource :  CYL3069100614 Datasheet

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    Contents: 2 x 1 mL aliquots containing 1.08 x 106 cells/mL in 10% DMSO at passage 14.
    Storage: Vials are to be stored in liquid N2.
    GMO: This product contains genetically modified organisms.
    Reference 1: 1. Decher, N., Barth, A.S., Gonzalez, T., Steinmeyer, K. and Sanguinetti, M.C. (2004). Novel KChIP2 isoforms increase functional diversity of transient outward potassium currents. J Physiol 557, 761-772.
    Reference 2: 2. Deschenes. I., DiSilvestre, D., Juang, G.J., Wu, R.C., An, W.F. and Tomaselli, G.F. (2002). Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to) Circulation 106, 423-429.
    Reference 3: 3. Diochot, S., Drici, M.D., Moinier, D., Fink, M. and Lazdunski, M. (1999). Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis. Br J Pharmacol 126, 251-263.
    Reference 4: 4. Kuo, H.C., Cheng, C.F., Clark, R.B., Lin, J.J., Lin, J.L., Hoshijima, M., Nguyen-Tran, V.T., Gu, Y., Ikeda, Y., Chu, P.H., Ross, J., Giles, W.R. and Chien, K.R. (2001). A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a comp
    Reference 5: 5. Nerbonne, J.M. (2000). Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium. J Physiol (Lond) 525, 285-298.