CYL3066 - PrecisION™ hTRPA1-HEK Recombinant Stable Cell Line

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  • Product Description

    Recombinant HEK293 cell line expressing the human TRPA1 transient receptor potential cation channels, subfamily A, member 1 (ankyrin-like protein, accession numbers Y10601 / NM_007332).

    Additional Resource :  CYL3066100614 Datasheet

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    Contents: 2 x 1 mL aliquots containing 1.15 x 106 cells/mL in 10% DMSO at passage 8.
    Storage: Vials are to be stored in liquid N2.
    GMO: This product contains genetically modified organisms.
    Reference 1: Bandell, M., Story, G.M., Hwang, S.W., Viswanath, V., Eid, S.R., Petrus, M.J., Earley, T.J. and Patapoutian, A. (2004). Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41, 849-857.
    Reference 2: 2. Garcia-Anoveros, J. and Nagata, K. (2007). Trpa1. Handb Exp Pharmacol, 347-362.
    Reference 3: 3. Hinman, A., Chuang, H.H., Bautista, D.M. and Julius, D. (2006). TRP channel activation by reversible covalent modification. Proc Natl Acad Sci U S A 103, 19564-19568.
    Reference 4: 4. Klionsky, L., Tamir, R., Gao, B., Wang, W., Immke, D.C., Nishimura, N. and Gavva, N.R. (2007). Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists. Mol Pain 3, 39.
    Reference 5: 5. Kwan, K.Y., Allchorne, A.J., Vollrath, M.A., Christensen, A.P., Zhang. D.S., Woolf. C.J. and Corey, D.P. (2006). TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron 50, 277-289.