CYL3059 - PrecisION™ hKv7.2/hKv7.3-CHO Recombinant Stable Cell Line

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  • Product Description

    Recombinant CHO-K1 cell line co-expressing the human Kv7.2 (voltage-gated potassium channel, KQT-like subfamily, member 2 (KCNQ2), accession number Y15065) and the human Kv7.3 (voltage-gated potassium channel, KQT-like subfamily, member 3 (KCNQ3), accession number NM_004519).

    Additional Resource :  CYL3059100614 Datasheet

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    Contents: 2 x 1 mL aliquots containing 1.58 x 106 cells/mL in 7.5% DMSO at passage 10.
    Storage: Vials are to be stored in liquid N2.
    GMO: This product contains genetically modified organisms.
    Reference 1: 1. Adams, P. R., Brown, D. A., and Constanti, A. (1982) M-currents and other potassium currents in bullfrog sympathetic neurones J Physiol 330, 537-572.
    Reference 2: 2. Brown, D. A., and Adams, P. R. (1980) Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone Nature 283(5748), 673-676.
    Reference 3: 3. Chung, H. J., Jan, Y. N., and Jan, L. Y. (2006) Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains Proc Natl Acad Sci U S A 103(23), 8870-8875.
    Reference 4: 4. Cooper, E. C. (2001) Potassium channels: how genetic studies of epileptic syndromes open paths to new therapeutic targets and drugs Epilepsia 42 Suppl 5, 49-54.
    Reference 5: 5. Costa, A. M., and Brown, B. S. (1997) Inhibition of M-current in cultured rat superior cervical ganglia by linopirdine: mechanism of action studies Neuropharmacology 36(11-12), 1747-1753.