CYL3050 - PrecisION™ rNav1.8-ND7 Recombinant Stable Cell Line

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  • Product Description

    Recombinant ND7-23 (rat DRG/mouse neuroblastoma hybrid) cell line expressing the rat Nav1.8 (type X voltage-gated sodium channel alpha subunit (Scn10a), Accession number U53833).

    Additional Resource :  CYL3050100614 Datasheet

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    Contents: 2 x 1 mL aliquots containing 1.0 x 106 cells/mL in 10% DMSO at passage 7.
    Storage: Vials are to be stored in liquid N2.
    GMO: This product contains genetically modified organisms.
    Reference 1: 1. Dekker, L.V., Daniels, Z., Hick, C., Elsegood, K., Bowden, S., Szestak, T.,Burley, J.R., Southan, A., Cronk, D. and James, I.F. (2005). Analysis of human Nav1.8 expressed in SH-SY5Y neuroblastoma cells. Eur. J. Pharmacol. 528. 52-58.
    Reference 2: 2. John, V.H., Main, M.J., Powell, A.J., Gladwell, Z.M., Hick, C., Sidhu, H.S., Clare, J.J., Tate, S. and Trezise, D.J. (2004). Heterologous expression and functional analysis of rat Nav1.8 (SNS) voltage-gated sodium channels in the dorsal root gangl
    Reference 3: 3. Leffler, A., Reiprich, A., Mohapatra, D.P. and Nau, N. (2006). Use-dependent block by lidocaine but not amitriptyline is more pronounced in TTX-resistant Nav1.8 than in TTX-sensitive Na channels. J. Pharm. Exp. Ther. in press.
    Reference 4: 4. Schroeder, K., Neagle, B., Trezise D.J. and Worley, J. (2003) IonWorksTM HT: a new high-throughput electrophysiology measurement platform. J. Biomol Screen 8 (1): 50-64.
    Reference 5: 5. Zhou, X., Dong, X-W., Crona, J., Maguire, M. and Priestley, T. (2003). Vinpocetine is a potent blocker of rat Nav1.8 tetrodotoxin-resistant sodium channels. J. Pharm. Exp. Ther 306. 498-504.