CYL3042 - PrecisION™ hHCN3-HEK Recombinant Stable Cell Line

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  • Product Description

    Recombinant HEK293 cell line expressing the human hyperpolarization-activated, cyclic nucleotide-gated potassium channel 3 (HCN3).

    Additional Resource :  CYL3042091114 Datasheet

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    Contents: 2 x 1 mL aliquots containing 1.08 x 106 cells/mL in 10% DMSO at passage 11.
    Storage: Vials are to be stored in liquid N2.
    GMO: This product contains genetically modified organisms.
    Reference 1: 1. Altomare, C., Terragni, B., Brioschi, C., Milanesi, R., Pagliuca, C., Viscomi, C., Moroni, A., Baruscotti, M., and DiFrancesco, D. (2003) Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node.
    Reference 2: 2. Brewster, A. L., Bernard, J. A., Gall, C. M., and Baram, T. Z. (2005) Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. Neurobiol Dis 19(1-2), 200
    Reference 3: 3. Chaplan, S. R., Guo, H. Q., Lee, D. H., Luo, L., Liu, C., Kuei, C., Velumian, A. A., Butler, M. P., Brown, S. M., and Dubin, A. E. (2003) Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain. J Neurosci 23(4), 1169-1178.
    Reference 4: 4. Chen, S., Wang, J., and Siegelbaum, S. A. (2001) Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide. J Gen Physiol 117(5), 491-504.
    Reference 5: 5. Mistrik, P., Mader, R., Michalakis, S., Weidinger, M., Pfeifer, A., and Biel, M. (2005) The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides. J Biol Chem 280(29), 27