CYL3039 - PrecisION™ hERG-HEK Recombinant Stable Cell Line

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  • Product Description

    Recombinant HEK293 cell line expressing the human ERG (ether-a-go-go related gene) potassium channel, accession number U04270.

    Additional Resource :  CYL3039090314 Datasheet

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    Contents: 2 x 1 mL aliquots containing 1.68 x 106 cells/mL in 10% DMSO at passage 11.
    Storage: Vials are to be stored in liquid N2.
    GMO: This product contains genetically modified organisms.
    Reference 1: 1. Mohammad, S., Zhou, Z., Gong, Q. and January, C.T. (1997) Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride. Am J Physiol. 273(5 Pt 2): H2534-8.
    Reference 2: 2. Rampe, D., Roy, M.L., Dennis, A., and Brown, A.M. (1997) A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG. FEBS Lett. 417(1): 28-32.
    Reference 3: 3. Schroeder, K., Neagle, B., Trezise D.J. and Worley, J. (2003) IonWorksTM HT: a new high-throughput electrophysiology measurement platform. J. Biomol Screen 8 (1): 50-64.
    Reference 4: 4. Walker, B.D., Singleton, C.B., Bursill, J.A., Wyse, K.R., Valenzuela, S.M., Qiu, M.R., Breit, S.N. and Campbell, T.J. (1999) Inhibition of the human ether-a-go-go-related gene (HERG) potassium channel by cisapride: affinity for open and inactivate
    Reference 5: 5. Yao, J-A., Du, X., Lu, D., Baker, R.L., Daharsh, E. and Atterson (2005) Estimation of potency of HERG channel blockers: Impact of voltage protocol and temperature. J Pharmacol Toxicol Meths. 52: 146-153.