CYL3038 - PrecisION hERG-CHO Recombinant Cell Line

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  • Product Description

    Recombinant CHO-K1 cell line expressing the human ERG (ether-a-go-go related gene) potassium channel (accession number U04270).

    Additional Resource :  CYL3038091114 Datasheet

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    Contents: 2 x 1 mL aliquots containing 1.62 x 106 cells/mL in 7.5% DMSO at passage 14.
    Storage: Vials are to be stored in liquid N2.
    GMO: This product contains genetically modified organisms.
    Reference 1: 1. Kirsch GE, Trepakova ES, Brimecombe JC, Sidach SS, Erickson HD, Kochan MC, Shyjka LM, Lacerda AE & Brown AM. (2004). Variability in the measurement of hERG potassium channel inhibition: effects of temperature and stimulus pattern. J Pharmacol Toxi
    Reference 2: 2. Mohammad S, Zhou Z, Gong Q & January CT. (1997). Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride. Am J Physiol 273, H2534-2538.
    Reference 3: 3. Rampe D, Roy ML, Dennis A & Brown AM. (1997). A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG. FEBS Lett 417, 28-32.
    Reference 4: 4. Schroeder, K., Neagle, B., Trezise D.J. and Worley, J. (2003) IonWorksTM HT: a new high-throughput electrophysiology measurement platform. J. Biomol Screen 8 (1): 50-64.
    Reference 5: 5. Walker BD, Singleton CB, Bursill JA, Wyse KR, Valenzuela SM, Qiu MR, Breit SN & Campbell TJ. (1999). Inhibition of the human ether-a-go-go-related gene (HERG) potassium channel by cisapride: affinity for open and inactivated states. Br J Pharmacol
    Reference 6: 6. Yao JA, Du X, Lu D, Baker RL, Daharsh E & Atterson P. (2005). Estimation of potency of HERG channel blockers: impact of voltage protocol and temperature. J Pharmacol Toxicol Methods 52, 146-153.