CYL3025 - PrecisION™ hNav1.8/ beta 1-HEK Recombinant Stable Cell Line

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  • Product Description

    Recombinant HEK293 cell line expressing the human Nav1.8 (accession number AF117907; tetrodotoxin-resistant voltage-gated sodium channel type X (SCN10A)) and the human sodium channel beta 1 subunit (accession number NM_001037; SCN1B).

    Additional Resource :  CYL3025091014 Datasheet

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    Contents: 2 x 1 mL aliquots containing 1.2 x 106 cells/mL in 10% DMSO at passage 17.
    Storage: Vials are to be stored in liquid N2.
    GMO: This product contains genetically modified organisms.
    Reference 1: 1. Akiba, I., Seki, T., Mori, M., Iizuka, M., Nishimura, S., Sasaki, S., Imoto, K. and Barsoumian, E.L. (2003). Stable expression and characterization of human PN1 and PN3 sodium channels. Receptors Channels 9, 291-299.
    Reference 2: 2. Akopian, A.N., Sivilotti, L. and Wood, J.N. (1996). A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature 379, 257-262.
    Reference 3: 3. Jarvis, M.F., Honore, P., Shieh, C.C., Chapman, M., Joshi, S., Zhang, X.F., Kort, M., Carroll, W., Marron, B., Atkinson, R., Thomas, J., Liu, D., Krambis, M., Liu, Y., McGaraughty, S., Chu, K., Roeloffs, R., Zhong, C., Mikusa, J.P., Hernandez, G.,
    Reference 4: 4. Leffler, A., Reiprich, A., Mohapatra, D.P. and Nau, C. (2007). Use-dependent block by lidocaine but not amitriptyline is more pronounced in tetrodotoxin (TTX)-Resistant Nav1.8 than in TTX-sensitive Na+ channels. J Pharmacol Exp Ther 320, 354-364.
    Reference 5: 6. Rabert, D.K., Koch, B.D., Ilnicka, M., Obernolte, R.A., Naylor, S.L., Herman, R.C., Eglen, R.M., Hunter, J.C. and Sangameswaran, L. (1998). A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A. Pain 78,
    Reference 6: 7. Vijayaragavan, K., O'Leary, M.E. and Chahine, M. (2001). Gating properties of Na(v)1.7 and Na(v)1.8 peripheral nerve sodium channels. J Neurosci 21, 7909-7918.