CYL3024 - PrecisION™ hNav1.4-HEK Recombinant Stable Cell Line

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  • Product Description

    Recombinant CHO-K1 cell line expressing the human Nav1.4 (type IV voltage-gated sodium channel alpha subunit, skeletal muscle).

    Additional Resource :  CYL3024090214 Datasheet

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    Contents: 2 x 1 mL aliquots containing 1.05 x 106 cells/mL in 10% DMSO at passage 10.
    Storage: Vials are to be stored in liquid N2.
    GMO: This product contains genetically modified organisms.
    Reference 1: 1. Bennett E. S. (2004). Channel activation voltage alone is directly altered in an isoform-specific manner by Na(v1.4) and Na(v1.5) cytoplasmic linkers. J Membr Biol 197, 155-168.
    Reference 2: 2. Catterall W. A., Goldin A. L. and Waxman S. G. (2005). International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pharmacol Rev 57, 397-409.
    Reference 3: 3. Chahine M., Bennett P. B., George A. L. Jr. and Horn R. (1994). Functional expression and properties of the human skeletal muscle sodium channel. Pflugers Arch 427, 136-142.
    Reference 4: 4. Cruz L. J., Gray W. R., Olivera B. M., Zeikus R. D., Kerr L., Yoshikami D. and Moczydlowski E. (1985). Conus geographus toxins that discriminate between neuronal and muscle sodium channels. J Biol Chem 260, 9280-9288.
    Reference 5: 5. Makielski J. C., Limberis J., Fan Z. and Kyle J. W. (1999). Intrinsic lidocaine affinity for Na channels expressed in Xenopus oocytes depends on alpha (hH1 vs. rSkM1) and beta 1 subunits. Cardiovasc Res 42, 503-509.
    Reference 6: 6. Schroeder, K., Neagle, B., Trezise D. J. and Worley, J. (2003) IonWorksTM HT: a new high-throughput electrophysiology measurement platform. J. Biomol Screen 8 (1): 50-64.