CYL3023 - PrecisION™ hNav1.2-CHO Recombinant Stable Cell Line

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  • Product Description

    Recombinant CHO-K1 cell line expressing the human Nav1.2 (type II voltage-gated sodium channel alpha subunit, SCN2A).

    Additional Resource :  CYL3023090214 Datasheet

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    Contents: 2 x 1 mL aliquots containing 1.20 x 106 cells/mL in 10% DMSO at passage 6.
    Storage: Vials are to be stored in liquid N2.
    GMO: This product contains genetically modified organisms.
    Reference 1: 1. Boccaccio, A., Moran, O., Keiji, K. and Conti, F. (1999). Tonic and phasic tetrodotoxin block of sodium channels with point mutations in the outer pore region. Biophysical Journal 77, 229-240.
    Reference 2: 2. McEwen, D.P., Meadows ,L.S, Chen, C., Thyagarajan, V. and Isom, L.L. (2004).Sodium channel β1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin. Journal of Biological C
    Reference 3: 3. Rush, A.M., Dib-Hajj, S.D. and Waxman, S.G. (2005). Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones. Journal of Physiology 564.3, 803-815.
    Reference 4: 4. Schroeder, K., Neagle, B., Trezise D.J. and Worley, J. (2003) IonworksTM HT: a new high-throughput electrophysiology measurement platform. J. Biomol Screen 8 (1): 50-64.
    Reference 5: 5. Weiser, T. (2005) Comparison of the effects of four Na+ channel analgesics on TTX-resistant Na currents in rat sensory neurons and recombinant Nav1.2 channels. Neuroscience Letters In Press
    Reference 6: 6. Yarov-Yarovoy V., Brown, J., Sharp, E.M., Clare, J.J., Scheuer, T. and Catterall, W.A. (2001). Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.