CYL3017 - PrecisION™ hKv1.4-CHO Recombinant Stable Cell Line

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  • Product Description

    Recombinant CHO-K1 cell line expressing the human Kv1.4 potassium channel (accession number NM_002233).

    Additional Resource :  CYL3017092314 Datasheet

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    Contents: 2 x 1 mL aliquots containing 1.02 x 106 cells/mL in 10% DMSO at passage 12.
    Storage: Vials are to be stored in liquid N2.
    GMO: This product contains genetically modified organisms.
    Reference 1: 1. Bett, G.C.L. and Rasmusson, R.L. (2004). Inactivation and recovery in Kv1.4 K+ channels: lipophilic interactions at the intracellular mouth of the pore. J Physiol (Lond) 556, 109-120.
    Reference 2: 2. Claydon, T.W., Boyett, M.R., Sivaprasadarao, A., Ishii, K., Owen, J.M., O'Beirne, H.A., Leach, R., Komukai, K. and Orchard, C.H. (2000). Inhibition of the K+ channel kv1.4 by acidosis: protonation of an extracellular histidine slows the recovery f
    Reference 3: 3. Coetzee, W.A., Amarillo, Y., Chiu, J., Chow, A., Lau, D., McCormack, T., Moreno, H., Nadal, M.S., Ozaita, A., Pountney, D., Saganich, M., Vega-Saenz de Miera, E. and Rudy, B. (1999). Molecular diversity of K+ channels. Ann N Y Acad Sci 868, 233-28
    Reference 4: 4. Judge, S.I., Yeh, J.Z., Goolsby, J.E., Monteiro, M.J. and Bever, C.T., Jr. (2002). Determinants of 4-aminopyridine sensitivity in a human brain kv1.4 k(+) channel: phenylalanine substitutions in leucine heptad repeat region stabilize channel close
    Reference 5: 5. Po, S., Snyders, D.J., Baker, R., Tamkun, M.M. and Bennett, P.B. (1992). Functional expression of an inactivating potassium channel cloned from human heart. Circ Res 71, 732-736.