Tie2 Human RTK Kinase Enzymatic Radiometric LeadHunter Assay [10 μM ATP] - TW

Background Information:

The TIE family of receptor tyrosine kinases comprises two members, TIE1 and TIE2 (Angiopoietin 1 receptor, Tyrosine-protein kinase receptor TIE-2, Tyrosine-protein kinase receptor TEK, P140 TEK, Tunica interna endothelial cell kinase, CD202b antigen, EC 2.7.1.112 ). These receptors are expressed predominantly in endothelial cells and are essential for vessel formation where they are required for the later stages of angiogenesis and vessel maintenance. TIE2 has roles in control of microvessel sprouting, integrity, and maturation. Angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) have been identified as ligands of TIE2 receptor, which may regulate endothelial cell proliferation, differentiation and guide the proper patterning of endothelial cells during blood vessel formation. Inhibitors of TIE2 may inhibit vascular healing and tumor angiogenesis.

Family:

Kinase

Sub Family:

RTK

Class:

Protein Tyrosine

Protein Name:

TIE2

Uniprot Number:

Q02763

Protein Aliases:

Endothelial tyrosine kinase|Tunica interna endothelial cell kinase|Tyrosine kinase with Ig and EGF homology domains-2|Tyrosine-protein kinase receptor TEK|Tyrosine-protein kinase receptor TIE-2|hTIE2|p140 TEK|CD antigen CD202b

Gene Name:

TEK

Gene ID:

7010

Gene Aliases:

TIE2|TIE-2|VMCM1|CD202b

Accession Number:

NM_000459

Organism:

Human

Construct Details:

Fragment (771-end), Recombinant