MALT1 Human Paracaspase Cysteine Peptidase Enzymatic LeadHunter Assay - TW

Background Information:

MALT1 (Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1) is a cysteine protease that plays a crucial role in the activation of NF-κB signaling pathways, particularly in T and B lymphocytes. MALT1 functions as both a scaffold protein and a paracaspase, forming part of the CBM signalosome complex that is essential for lymphocyte activation and proliferation. MALT1 has been implicated in various lymphoid malignancies and has emerged as a potential therapeutic target for certain lymphomas and autoimmune disorders. However, the inhibition of MALT1 is associated with immunotoxicity, specifically affecting thymic Treg output and development.

Family:

Protease

Sub Family:

Caspase

Class:

Cysteine Peptidase

Protein Name:

MALT1

Uniprot Number:

Q9UDY8

Protein Aliases:

MALT lymphoma-associated translocation;Paracaspase

Gene Name:

MALT1

Gene ID:

10892

Gene Aliases:

PCASP1;MALT1 protease;paracaspase 1

Accession Number:

NM_006785

Organism:

Human

Construct Details:

Full length, recombinant