GSK3beta Human CMGC Kinase Enzymatic Radiometric LeadHunter Assay [10 μM ATP] - TW

Background Information:

Glycogen synthase kinase-3 (GSK-3) is a protein kinase that was originally identified as a regulator of glycogen synthase, a key enzyme in glycogen metabolism. There are two isoforms of GSK-3, GSK-3a and GSK-3b, and they are strictly regulated via phosphorylation. Phosphorylation of GSK-3b on Ser9 by protein kinase B (PKB) causes its inactivation and is the primary mechanism responsible for growth factor inhibition of this kinase. Activation of GSK-3b is dependent upon the phosphorylation of Tyr216. Upon activation, it has been shown to phosphorylate a number of different cellular proteins, including p53, c-Myc, c-Jun, heat shock factor-1 (HSF-1), and cyclin D1. GSK-3b also has been shown to phosphorylate aberrant sites on the microtubule associated protein tau, which is critical for the progression of Alzheimer’s disease. The inhibitors may have therapeutic opportunities for the treatment of diabetes, Alzheimer's disease, stroke and bipolar disorder.

Family:

Kinase

Sub Family:

CMGC

Class:

Protein Ser/Thr

Protein Name:

GSK3beta

Uniprot Number:

P49841

Protein Aliases:

Serine/threonine-protein kinase GSK3B

Gene Name:

GSK3B

Gene ID:

2932

Accession Number:

NM_001146156

Organism:

Human

Construct Details:

Fragment (2-end), Recombinant