Cav2.2 (N-type) Rat Calcium Ion Channel Binding Antagonist Radioligand LeadHunter Assay - FR

Background Information:

Voltage-gated calcium channels mediate calcium influx in response to membrane depolarization and regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression. They are members of a gene superfamily of transmembrane ion channel proteins that includes voltage-gated potassium and sodium channels. Pharmacology of the three families of calcium channels is quite distinct. N-Type calcium channels are relatively insensitive to L-Type channel blockers and are specifically blocked with high affinity by peptide toxins from spiders and marine snails. The peptide toxins are potent blockers of synaptic transmission.

Family:

Ion Channel

Sub Family:

Calcium

Class:

Voltage-Gated

Protein Name:

Cav2.2 (N-type)

Uniprot Number:

Q00975 (human)

Gene Name:

CACNA1B

Gene ID:

774

Gene Aliases:

Cav2.2|CACNN

Organism:

Rat

Tissue:

Brain