23-029 - UbcH5a Protein, active, 50 ug

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23-029
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  • Product Description

    Ubiquitin-conjugating (E2) enzymes are characterized by the presence of a highly conserved ubiquitin-conjugating domain which accommodates ATP-activated ubiquitin (Ub) via a covalently linked thioester onto its active-site residue. E2 enzymes act via selective protein-protein interactions with the ubiquitin-activating E1 enzyme and ubiquitin ligase E3 enzymes and are able to differentiate effects on downstream substrates, either with a single Ub molecule or an Ub chain. While E3s are involved in substrate selection, E2s are the main determinants for selection of the lysine to construct Ub chains, which thereby directly control the cellular fate of the substrate. The UbcH5 family (UbcH5a, UbcH5b and UbcH5c) have been shown to be the most active class of E2 enzymes in cell extracts and are associated with the regulation of a number of transcription factors, including p53 and c-Myc.

    Additional Resource: 23-029_D11EP014N_Datasheet

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    Item Unit of Measure: EA
    Quantity: 50 ug
    Applications: Enzyme Assay
    Entrez Gene Number: NM_003338 (GenBank Number)
    Species: Human
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