23-026 - SCF-TrCP1 Protein Complex, Active, 10 ug

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    The SCF (Skp1-Cul1-F-box protein) complexes represent the largest family of ubiquitin-protein ligases and mediate the ubiquitination of a broad spectrum of regulatory and signalling proteins in diverse cellular pathways. The SCF consists of three invariant components, Skp1, Cul1, and Rbx1 and an interchangeable subunit, an F-box protein which is responsible for recruiting specific substrates to be ubiquitinated by the SCF. SCF βTrCP mediates the ubiquitination and subsequent proteasomal degradation of a variety of proteins involved in various cellular processes, these include IκBα, an inhibitor of the transcription factor NFκB and β-catenin which is involved in the Wnt signalling pathway. A number of cancers, including those in breast, colon and pancreatic tissue have been associated with the deregulation of SCF βTrCP1

    Additional Resource: 23-026_D11CP014N_Datasheet

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    Item Unit of Measure: EA
    Quantity: 10 ug
    Applications: Enzyme Assay
    Entrez Gene Number: NM_033637 (βTrCP1, contains the amino acid substitution E353D with reference to GenBank NM_033637) (GenBank Number)-NM_170679 (Skp1) (GenBank Number)-NM_003592 (Cul1) (GenBank Number)-NM_014248 (Rbx1) (GenBank Number)
    Species: Human