14-779 - MKP5, active,10 ug

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14-779
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  • Product Description

    Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members ofthis family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.

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    Item Unit of Measure: EA
    Quantity: 10 ug
    Storage: On receipt of material store at -70°C. Unopened reagent is stable for a minimum of 1 year from date of shipment when stored at recommended storage temperature. Avoid repeat freeze/thaw cycles.
    Applications: Enzyme Assay
    Protein or Enzyme Type: Phosphatases; Signal Transduction; Recombinant Protein
    Entrez Gene Number: NM_007207
    Gene Symbol: DUSP10-MKP5
    UniProt Number: Q9Y6W6
    Species: Human
    Source: expressed in E. coli.
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