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14-522-K - Abl (T315I) Protein, active

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14-522-K
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  • Product Description

    N-terminal His6-tagged recombinant human Abl, residues 27-end containing the T315I mutation Contains the gatekeeper mutation T315I in the ATP-binding domain.  This mutation decreases the sensitivity to Gleevec® by more than 200-fold as compared to the wild type sequence.

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    Item Unit of Measure: UG
    Storage: On receipt of material store at -70°C. Unopened reagent is stable for a minimum of 1 year from date of shipment when stored at recommended storage temperature. Avoid repeat freeze/thaw cycles.
    Applications: Enzyme Assay
    Entrez Gene Number: NM_005157.3;NM_007313.2
    Gene Symbol: ABL1;JTK7;ABL;p150;v-abl;c-ABL;bcr/abl
    Species: Human
    Source: Expressed by baculovirus in Sf21 insect cells
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